Not all of us will be Picasso or Einstein, but I feel that almost everyone has the capacity to find a fulfilling and creative life for themselves. I'm influenced here by books like Do What You Love and Feel the Fear and Do It Anyway and How to Find the Work You Love.
The basic point boils down to this: find what you love and are passionate about in life, then do the hard work to incorporate it into your day-to-day living. The trick is that it isn't easy; in fact it's really fucking hard. Most people are lulled into a work/life that they're minimally contented with. Finding and maintaining a creative life is a monumental task with monumental rewards.
This doesn't mean that everyone should give up working at Modell's or WalMart and become an artist. But it does mean that if you love hockey or boating or nature or sculpture, you can find a way to make what you love an intrinsic part of your life.
As Woody Allen put it: 90% of life is showing up. That can also equate to showing up in front of the canvas, PC, amp, newspaper, journal, etc. Show up for yourself, and find what you need out of life.
Then go get it.